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Sources & further reading Retraction notice to "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System" the 2014 paper establishing dihexa's proposed mechanism was retracted in April 2025

In this assay, the 30 min incubation duration was chosen to be optimal because of the inherently cytotoxic nature of CuCl 2 and Cu(OAc) 2 towards HaCaT keratinocytes, as they were observed to cause substantial cell death at a duration longer than 30 mins

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Comparison table This table reinforces a critical point

Published research includes effects on collagen and extracellular matrix biology, partly via copper-dependent lysyl oxidase